APC2 Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. Belongs to the cullin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 9q34.3
Cellular Component:  anaphase-promoting complex; cytosol; nucleoplasm
Molecular Function:  protein binding; ubiquitin protein ligase binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of synapse maturation; positive regulation of synaptic plasticity; protein K11-linked ubiquitination; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process
Reference #:  Q9UJX6 (UniProtKB)
Alt. Names/Synonyms: ANAPC2; anaphase promoting complex subunit 2; Anaphase-promoting complex subunit 2; ANC2; APC2; Cyclosome subunit 2; KIAA1406; RP11-350O14.5
Gene Symbols: ANAPC2
Molecular weight: 93,828 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene