occludin May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. Belongs to the ELL/occludin family. Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13 D1|13 53.23 cM
Cellular Component:  apical plasma membrane; apicolateral plasma membrane; bicellular tight junction; cell junction; cell surface; cell-cell junction; cytoplasmic vesicle; endocytic vesicle; integral component of membrane; lateral plasma membrane; membrane; plasma membrane
Molecular Function:  protein binding; protein domain specific binding
Biological Process:  bicellular tight junction assembly; cell-cell junction organization; response to interleukin-18
Reference #:  Q61146 (UniProtKB)
Alt. Names/Synonyms: AI503564; Occludin; Ocl; Ocln
Gene Symbols: Ocln
Molecular weight: 59,000 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene