NRIF3 Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component:  condensed chromosome kinetochore; cytoplasm; cytosol; membrane; nucleoplasm; nucleus
Molecular Function:  protein binding; protein C-terminus binding
Biological Process:  apoptotic process; cell adhesion; cell cycle; cell division; CENP-A containing nucleosome assembly; positive regulation of apoptotic process; regulation of transcription, DNA-templated; signal transduction
Reference #:  Q13352 (UniProtKB)
Alt. Names/Synonyms: beta 3 endonexin; Beta-3-endonexin; beta3-endonexin; CENP-R; CENPR; Centromere protein R; HSU37139; integrin beta 3 binding protein; integrin beta 3 binding protein (beta3-endonexin); Integrin beta-3-binding protein; integrin subunit beta 3 binding protein; ITGB3BP; NRIF3; Nuclear receptor-interacting factor 3; TAP20
Gene Symbols: ITGB3BP
Molecular weight: 20,194 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein