PTGES Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family. Note: This description may include information from UniProtKB.
Protein type: EC; Isomerase; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope
Chromosomal Location of human Ortholog: 9q34.11
Cellular Component:  endoplasmic reticulum membrane; integral component of membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm
Molecular Function:  glutathione binding; prostaglandin-E synthase activity
Biological Process:  acute inflammatory response; chronic inflammatory response; cyclooxygenase pathway; negative regulation of cell proliferation; prostaglandin biosynthetic process; prostaglandin metabolic process; response to calcium ion; response to cytokine; response to lipopolysaccharide; response to organic cyclic compound; response to retinoic acid; signal transduction
Reference #:  O14684 (UniProtKB)
Alt. Names/Synonyms: glutathione S-transferase 1-like 1; MGC10317; MGST-IV; MGST1-L1; MGST1-like 1; MGST1L1; Microsomal glutathione S-transferase 1-like 1; Microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; MPGES; mPGES-1; MPGES1; p53-induced apoptosis protein 12; p53-induced gene 12 protein; PGES; PIG12; PP102; PP1294; Prostaglandin E synthase; PTGES; TP53I12; tumor protein p53 inducible protein 12
Gene Symbols: PTGES
Molecular weight: 17,102 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene