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PTGES
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family. Note: This description may include information from UniProtKB.
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| Protein type: EC 5.3.99.3; Isomerase; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope |
| Chromosomal Location of human Ortholog: 9q34.11 |
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Cellular Component:
endoplasmic reticulum membrane; integral component of membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm
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Molecular Function:
glutathione binding; prostaglandin-E synthase activity
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Biological Process:
acute inflammatory response; chronic inflammatory response; cyclooxygenase pathway; negative regulation of cell proliferation; prostaglandin biosynthetic process; prostaglandin metabolic process; response to calcium ion; response to cytokine; response to lipopolysaccharide; response to organic cyclic compound; response to retinoic acid; signal transduction
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Reference #:
O14684
(UniProtKB)
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Alt. Names/Synonyms: glutathione S-transferase 1-like 1; MGC10317; MGST-IV; MGST1-L1; MGST1-like 1; MGST1L1; Microsomal glutathione S-transferase 1-like 1; Microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; MPGES; mPGES-1; MPGES1; p53-induced apoptosis protein 12; p53-induced gene 12 protein; PGES; PIG12; PP102; PP1294; Prostaglandin E synthase; PTGES; TP53I12; tumor protein p53 inducible protein 12
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Gene Symbols: PTGES
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Molecular weight:
17,102 Da
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Basal Isoelectric point:
9.59
Predict pI for various phosphorylation states
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