ARNT Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of human Ortholog: 1q21.3
Cellular Component:  aryl hydrocarbon receptor complex; chromatin; cytoplasm; nuclear aryl hydrocarbon receptor complex; nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
Molecular Function:  aryl hydrocarbon receptor binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  cell differentiation; embryonic placenta development; intracellular receptor signaling pathway; negative regulation of inflammatory response; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of glycolytic process; positive regulation of hormone biosynthetic process; positive regulation of protein sumoylation; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial growth factor production; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to hypoxia
Reference #:  P27540 (UniProtKB)
Alt. Names/Synonyms: ARNT; ARNT protein; Aryl hydrocarbon receptor nuclear translocator; BHLHE2; Class E basic helix-loop-helix protein 2; Dioxin receptor, nuclear translocator; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; hypoxia-inducible factor 1, beta subunit; Hypoxia-inducible factor 1-beta; TANGO
Gene Symbols: ARNT
Molecular weight: 86,636 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  mTOR Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein