ARNT Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm; nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription factor complex

Molecular Function: aryl hydrocarbon receptor binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enhancer binding; nuclear receptor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific double-stranded DNA binding; transcription coactivator activity; transcription factor binding

Biological Process: cell differentiation; embryonic placenta development; intracellular receptor signaling pathway; mRNA transcription by RNA polymerase II; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of glycolytic process; positive regulation of hormone biosynthetic process; positive regulation of protein sumoylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of transcription from RNA polymerase II promoter in response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to hypoxia; transcription, DNA-templated; xenobiotic metabolic process

Reference #: P27540 (UniProtKB)

Alt. Names/Synonyms: ARNT; ARNT protein; Aryl hydrocarbon receptor nuclear translocator; BHLHE2; Class E basic helix-loop-helix protein 2; Dioxin receptor, nuclear translocator; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; hypoxia-inducible factor 1, beta subunit; Hypoxia-inducible factor 1-beta; TANGO

Gene Symbols: ARNT

Molecular weight: 86,636 Da

Basal Isoelectric point: 6.11 Predict pI for various phosphorylation states

CST Pathways: Angiogenesis | mTOR Signaling

Protein-Specific Antibodies or siRNAs from Cell Signaling Technology^®

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ARNT

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