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OGFOD1
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. Belongs to the TPA1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.14.11.-; Oxidoreductase |
| Chromosomal Location of human Ortholog: 16q13 |
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Cellular Component:
cytoplasm; cytoplasmic stress granule; cytosol; nucleoplasm
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Molecular Function:
iron ion binding; L-ascorbic acid binding; peptidyl-proline 3-dioxygenase activity; peptidyl-proline dioxygenase activity; protein binding
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Biological Process:
cell population proliferation; peptidyl-proline hydroxylation; protein hydroxylation; regulation of translational termination; stress granule assembly
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Reference #:
Q8N543
(UniProtKB)
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Alt. Names/Synonyms: 2-oxoglutarate and iron dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; FLJ10826; KIAA1612; OGFD1; OGFOD1; Prolyl 3-hydroxylase OGFOD1; Termination and polyadenylation 1 homolog; TPA1; TPA1, termination and polyadenylation 1, homolog; uS12 prolyl 3-hydroxylase
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Gene Symbols: OGFOD1
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Molecular weight:
63,246 Da
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Basal Isoelectric point:
5.03
Predict pI for various phosphorylation states
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