OGFOD1 Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. Belongs to the TPA1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase
Chromosomal Location of human Ortholog: 16q13
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol; nucleoplasm
Molecular Function:  iron ion binding; L-ascorbic acid binding; peptidyl-proline 3-dioxygenase activity; peptidyl-proline dioxygenase activity; protein binding
Biological Process:  cell population proliferation; peptidyl-proline hydroxylation; protein hydroxylation; regulation of translational termination; stress granule assembly
Reference #:  Q8N543 (UniProtKB)
Alt. Names/Synonyms: 2-oxoglutarate and iron dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; FLJ10826; KIAA1612; OGFD1; OGFOD1; Prolyl 3-hydroxylase OGFOD1; Termination and polyadenylation 1 homolog; TPA1; TPA1, termination and polyadenylation 1, homolog; uS12 prolyl 3-hydroxylase
Gene Symbols: OGFOD1
Molecular weight: 63,246 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene