CD38 Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.99.20; EC 3.2.2.6; Hydrolase; Lyase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p15.32
Cellular Component:  basolateral plasma membrane; cell surface; integral component of membrane; membrane; nucleus; plasma membrane; secretory granule membrane
Molecular Function:  identical protein binding; NAD(P)+ nucleosidase activity; NAD+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; transferase activity
Biological Process:  apoptotic signaling pathway; artery smooth muscle contraction; B cell receptor signaling pathway; female pregnancy; long-term synaptic depression; NAD metabolic process; negative regulation of apoptotic process; negative regulation of bone resorption; negative regulation of neuron projection development; negative regulation of transcription, DNA-templated; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cytosolic calcium ion concentration; positive regulation of insulin secretion; positive regulation of transcription, DNA-templated; positive regulation of vasoconstriction; response to drug; response to estradiol; response to hydroperoxide; response to hypoxia; response to interleukin-1; response to progesterone; response to retinoic acid; signal transduction
Reference #:  P28907 (UniProtKB)
Alt. Names/Synonyms: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; ADPRC1; cADPr hydrolase 1; CD38; CD38 antigen (p45); CD38 molecule; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; T10
Gene Symbols: CD38
Molecular weight: 34,328 Da
Basal Isoelectric point: 7.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CD38

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB