ZDHHC21 Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. Belongs to the DHHC palmitoyltransferase family. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of human Ortholog: 9p22.3
Cellular Component:  endoplasmic reticulum; Golgi apparatus; Golgi membrane; plasma membrane
Molecular Function:  palmitoyltransferase activity; protein binding; protein-cysteine S-palmitoyltransferase activity
Biological Process:  adrenergic receptor signaling pathway; hair follicle development; peptidyl-L-cysteine S-palmitoylation; protein palmitoylation; protein targeting to membrane; regulation of establishment of endothelial barrier; regulation of leukocyte adhesion to arterial endothelial cell; regulation of nitric-oxide synthase activity; regulation of vascular associated smooth muscle contraction; sebaceous gland development
Reference #:  Q8IVQ6 (UniProtKB)
Alt. Names/Synonyms: 9130404H11Rik; DHHC-21; DHHC21; DNZ1; HSPC097; Palmitoyltransferase ZDHHC21; Probable palmitoyltransferase ZDHHC21; ZDH21; ZDHHC21; Zinc finger DHHC domain-containing protein 21; zinc finger DHHC-type containing 21; zinc finger DHHC-type palmitoyltransferase 21; zinc finger, DHHC domain containing 21; zinc finger, DHHC-type containing 21
Gene Symbols: ZDHHC21
Molecular weight: 31,385 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene