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ZDHHC21
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. Belongs to the DHHC palmitoyltransferase family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase |
| Chromosomal Location of human Ortholog: 9p22.3 |
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Cellular Component:
endoplasmic reticulum; Golgi apparatus; Golgi membrane; plasma membrane
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Molecular Function:
palmitoyltransferase activity; protein binding; protein-cysteine S-palmitoyltransferase activity
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Biological Process:
adrenergic receptor signaling pathway; hair follicle development; peptidyl-L-cysteine S-palmitoylation; protein palmitoylation; protein targeting to membrane; regulation of establishment of endothelial barrier; regulation of leukocyte adhesion to arterial endothelial cell; regulation of nitric-oxide synthase activity; regulation of vascular associated smooth muscle contraction; sebaceous gland development
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Reference #:
Q8IVQ6
(UniProtKB)
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Alt. Names/Synonyms: 9130404H11Rik; DHHC-21; DHHC21; DNZ1; HSPC097; Palmitoyltransferase ZDHHC21; Probable palmitoyltransferase ZDHHC21; ZDH21; ZDHHC21; Zinc finger DHHC domain-containing protein 21; zinc finger DHHC-type containing 21; zinc finger DHHC-type palmitoyltransferase 21; zinc finger, DHHC domain containing 21; zinc finger, DHHC-type containing 21
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Gene Symbols: ZDHHC21
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Molecular weight:
31,385 Da
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Basal Isoelectric point:
8.81
Predict pI for various phosphorylation states
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