GDE1 Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways. Belongs to the glycerophosphoryl diester phosphodiesterase family. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Phosphodiesterase
Chromosomal Location of Human Ortholog: 16p12.3
Cellular Component:  cytoplasmic vesicle membrane; integral component of membrane; plasma membrane
Molecular Function:  glycerophosphodiester phosphodiesterase activity; glycerophosphoinositol glycerophosphodiesterase activity; lysophospholipase activity; metal ion binding
Biological Process:  glycerophospholipid catabolic process; lipid metabolic process; N-acylethanolamine metabolic process; phospholipid metabolic process
Reference #:  Q9NZC3 (UniProtKB)
Alt. Names/Synonyms: 363E6.2; GDE1; Glycerophosphodiester phosphodiesterase 1; membrane interacting protein of RGS16; Membrane-interacting protein of RGS16; MIR16; RGS16-interacting membrane protein
Gene Symbols: GDE1
Molecular weight: 37,718 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB