VKORC1 Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. Belongs to the VKOR family. Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of human Ortholog: 16p11.2
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function:  protein binding; quinone binding; vitamin-K-epoxide reductase (warfarin-insensitive) activity; vitamin-K-epoxide reductase (warfarin-sensitive) activity
Biological Process:  blood coagulation; bone development; peptidyl-glutamic acid carboxylation; positive regulation of coagulation; regulation of blood coagulation; response to antibiotic; response to organic cyclic compound; response to organonitrogen compound; vitamin K metabolic process; xenobiotic metabolic process
Disease: Coumarin Resistance; Vitamin K-dependent Clotting Factors, Combined Deficiency Of, 2
Reference #:  Q9BQB6 (UniProtKB)
Alt. Names/Synonyms: EDTP308; FLJ00289; IMAGE3455200; MGC2694; MST134; MST576; phylloquinone epoxide reductase; vitamin K dependent clotting factors deficiency 2; Vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase complex, subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); VKCFD2; VKOR; VKOR1; VKORC1
Gene Symbols: VKORC1
Molecular weight: 18,235 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene