DLX3 Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Belongs to the distal-less homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: 
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding
Biological Process:  blood vessel development; odontoblast differentiation; odontogenesis of dentin-containing tooth; placenta development; positive regulation of transcription by RNA polymerase II
Disease: Amelogenesis Imperfecta, Type Iv; Trichodentoosseous Syndrome
Reference #:  O60479 (UniProtKB)
Alt. Names/Synonyms: AI4; distal-less homeo box 3; distal-less homeobox 3; DLX3; Homeobox protein DLX-3; TDO
Gene Symbols: DLX3
Molecular weight: 31,738 Da
Basal Isoelectric point: 8.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene