CHPT1 Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of human Ortholog: 12q23.2
Cellular Component:  Golgi membrane; integral component of membrane; intracellular membrane-bounded organelle; membrane
Molecular Function:  diacylglycerol binding; diacylglycerol cholinephosphotransferase activity; metal ion binding
Biological Process:  CDP-choline pathway; lipid metabolic process; phosphatidylcholine biosynthetic process; platelet activating factor biosynthetic process; regulation of cell growth
Reference #:  Q8WUD6 (UniProtKB)
Alt. Names/Synonyms: AAPT1-like protein; choline phosphotransferase 1; Cholinephosphotransferase 1; cholinephosphotransferase 1 alpha; CHPT1; CPT; CPT1; Diacylglycerol cholinephosphotransferase 1; hCPT1; phosphatidylcholine synthesizing enzyme
Gene Symbols: CHPT1
Molecular weight: 45,097 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene