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SOD3
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Belongs to the Cu-Zn superoxide dismutase family. Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.15.1.1; Oxidoreductase; Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 5 C1|5 27.92 cM |
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Cellular Component:
collagen-containing extracellular matrix; cytoplasm; extracellular region; extracellular space; nucleus
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Molecular Function:
antioxidant activity; copper ion binding; metal ion binding; oxidoreductase activity; protein binding; superoxide dismutase activity
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Biological Process:
removal of superoxide radicals; response to copper ion; response to hypoxia; superoxide metabolic process
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Reference #:
O09164
(UniProtKB)
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Alt. Names/Synonyms: AI314465; EC-S; EC-SOD; extracellular superoxide dismutase; Extracellular superoxide dismutase [Cu-Zn]; MGC13799; Sod3; SODE; superoxide dismutase 3, extracellular
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Gene Symbols: Sod3
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Molecular weight:
27,392 Da
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Basal Isoelectric point:
6.36
Predict pI for various phosphorylation states
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