SOD3 Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Belongs to the Cu-Zn superoxide dismutase family. Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 5 C1|5 27.92 cM
Cellular Component:  collagen-containing extracellular matrix; cytoplasm; extracellular region; extracellular space; nucleus
Molecular Function:  antioxidant activity; copper ion binding; metal ion binding; oxidoreductase activity; protein binding; superoxide dismutase activity
Biological Process:  removal of superoxide radicals; response to copper ion; response to hypoxia; superoxide metabolic process
Reference #:  O09164 (UniProtKB)
Alt. Names/Synonyms: AI314465; EC-S; EC-SOD; extracellular superoxide dismutase; Extracellular superoxide dismutase [Cu-Zn]; MGC13799; Sod3; SODE; superoxide dismutase 3, extracellular
Gene Symbols: Sod3
Molecular weight: 27,392 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene