PPP2CB PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Belongs to the PPP phosphatase family. PP-1 subfamily. Note: This description may include information from UniProtKB.

Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of rat Ortholog: 16q12.3

Cellular Component: chromosome, centromeric region; cytoplasm; cytosol; nucleus; protein phosphatase type 2A complex; spindle pole

Molecular Function: metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein heterodimerization activity; protein serine/threonine phosphatase activity; transmembrane transporter binding

Biological Process: apoptotic mitochondrial changes; mitotic cell cycle; negative regulation of gene expression; negative regulation of NF-kappaB transcription factor activity; negative regulation of Ras protein signal transduction; negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of microtubule binding; proteasome-mediated ubiquitin-dependent protein catabolic process; protein dephosphorylation; regulation of gene expression; response to antibiotic; response to endoplasmic reticulum stress; response to hydrogen peroxide; response to lead ion

Reference #: P62716 (UniProtKB)

Alt. Names/Synonyms: MGC94855; PP2A-beta; Pp2a2; PP2AB; Ppp2cb; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2A catalytic alpha subunit; protein phosphatase 2a, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

Gene Symbols: Ppp2cb

Molecular weight: 35,575 Da

Basal Isoelectric point: 5.21 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PPP2CB