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CMPK2
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. Belongs to the thymidylate kinase family. Among all investigated tumors, leukemia cells show the most abundant expression. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.4.14; EC 2.7.4.6; Kinase, other; Nucleotide Metabolism - pyrimidine |
| Chromosomal Location of mouse Ortholog: 12 A2|12 9.69 cM |
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Cellular Component:
cytoplasm; mitochondrion; nucleoplasm
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Molecular Function:
ATP binding; cytidylate kinase activity; kinase activity; nucleoside diphosphate kinase activity; nucleoside monophosphate kinase activity; nucleotide binding; thymidylate kinase activity; transferase activity; UMP kinase activity; UMP/dUMP kinase activity
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Biological Process:
cellular response to lipopolysaccharide; dTDP biosynthetic process; dTTP biosynthetic process; dUDP biosynthetic process; nucleoside monophosphate phosphorylation; phosphorylation; pyrimidine nucleotide biosynthetic process
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Reference #:
Q3U5Q7
(UniProtKB)
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Alt. Names/Synonyms: 1200004E04Rik; Cmpk2; cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; Nucleoside-diphosphate kinase; TDK; TDKI; thymidylate kinase homologue; Thymidylate kinase LPS-inducible member; Tyk; TYKi; UMP-CMP kinase 2, mitochondrial
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Gene Symbols: Cmpk2
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Molecular weight:
50,036 Da
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Basal Isoelectric point:
6.89
Predict pI for various phosphorylation states
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