PRSS22 Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. Belongs to the peptidase S1 family. Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  extracellular region
Molecular Function:  serine-type endopeptidase activity
Biological Process:  proteolysis
Reference #:  Q9GZN4 (UniProtKB)
Alt. Names/Synonyms: Brain-specific serine protease 4; BSSP-4; BSSP4; hBSSP-4; MGC9599; prosemin; protease, serine S1 family member 22; protease, serine, 22; PRSS22; PRSS26; Serine protease 22; Serine protease 26; SP001LA; Tryptase epsilon
Gene Symbols: PRSS22
Molecular weight: 33,732 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB