PLA2G2D PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. Belongs to the phospholipase A2 family. Broadly expressed. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 1p36.12
Cellular Component:  extracellular region
Molecular Function:  heparan sulfate proteoglycan binding; heparin binding; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine); phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process:  arachidonic acid secretion; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; inflammatory response; lipid catabolic process; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylinositol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling
Reference #:  Q9UNK4 (UniProtKB)
Alt. Names/Synonyms: GIID sPLA2; Group IID secretory phospholipase A2; PA2GD; Phosphatidylcholine 2-acylhydrolase 2D; phospholipase A2 group IID; phospholipase A2, group IID; PLA2G2D; PLA2IID; secretory phospholipase A2s; Secretory-type PLA, stroma-associated homolog; sPLA2-IID; sPLA2S; SPLASH
Gene Symbols: PLA2G2D
Molecular weight: 16,546 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene