OLAH Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). Belongs to the thioesterase family. Detected both in lactating and non-lactating breast epithelium (at protein level) (PubMed:6589427). Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients (PubMed:17082220). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of human Ortholog: 10p13
Cellular Component:  cytosol
Molecular Function:  dodecanoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-CoA hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-CoA hydrolase activity
Biological Process:  lipid biosynthetic process; medium-chain fatty acid biosynthetic process
Reference #:  Q9NV23 (UniProtKB)
Alt. Names/Synonyms: augmented in rheumatoid arthritis 1; AURA1; FLJ11106; MGC51852; OLAH; Oleoyl-ACP hydrolase; oleoyl-acyl-carrier-protein hydrolase; S-acyl fatty acid synthase thioesterase, medium chain; SAST; TE2; THEDC1; Thioesterase 2; thioesterase domain containing 1; Thioesterase domain-containing protein 1; Thioesterase II
Gene Symbols: OLAH
Molecular weight: 29,931 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene