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OLAH
Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). Belongs to the thioesterase family. Detected both in lactating and non-lactating breast epithelium (at protein level) (PubMed:6589427). Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients (PubMed:17082220). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.2.14; Hydrolase; Lipid Metabolism - fatty acid biosynthesis |
| Chromosomal Location of human Ortholog: 10p13 |
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Cellular Component:
cytosol
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Molecular Function:
dodecanoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; myristoyl-CoA hydrolase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; palmitoyl-CoA hydrolase activity
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Biological Process:
lipid biosynthetic process; medium-chain fatty acid biosynthetic process
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Reference #:
Q9NV23
(UniProtKB)
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Alt. Names/Synonyms: augmented in rheumatoid arthritis 1; AURA1; FLJ11106; MGC51852; OLAH; Oleoyl-ACP hydrolase; oleoyl-acyl-carrier-protein hydrolase; S-acyl fatty acid synthase thioesterase, medium chain; SAST; TE2; THEDC1; Thioesterase 2; thioesterase domain containing 1; Thioesterase domain-containing protein 1; Thioesterase II
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Gene Symbols: OLAH
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Molecular weight:
29,931 Da
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Basal Isoelectric point:
5.81
Predict pI for various phosphorylation states
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