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rabphilin 3A
Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of rat Ortholog: 12q16 |
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Cellular Component:
cholinergic synapse; dendritic spine; extrinsic component of membrane; extrinsic component of synaptic vesicle membrane; membrane; neuromuscular junction; neuron projection; postsynaptic membrane; presynapse; protein-containing complex; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane
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Molecular Function:
calcium ion binding; calcium-dependent phospholipid binding; inositol 1,4,5 trisphosphate binding; metal ion binding; phosphate ion binding; phosphatidylinositol-4,5-bisphosphate binding; phospholipid binding; protein binding; protein-containing complex binding; selenium binding; small GTPase binding; zinc ion binding
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Biological Process:
dendritic spine organization; exocytosis; intracellular protein transport; regulation of calcium ion-dependent exocytosis; regulation of NMDA receptor activity; spontaneous neurotransmitter secretion; synaptic vesicle priming
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Reference #:
P47709
(UniProtKB)
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Alt. Names/Synonyms: Exophilin-1; rabphilin 3A; rabphilin 3A homolog; Rabphilin-3A; RP3A; Rph3a
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Gene Symbols: Rph3a
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Molecular weight:
75,832 Da
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Basal Isoelectric point:
8.55
Predict pI for various phosphorylation states
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