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RFNG
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. Belongs to the glycosyltransferase 31 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.222; Membrane protein, integral; Motility/polarity/chemotaxis; Transferase |
| Chromosomal Location of human Ortholog: 17q25.3 |
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Cellular Component:
extracellular region; Golgi membrane
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Molecular Function:
metal ion binding; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
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Biological Process:
animal organ morphogenesis; cell differentiation; nervous system development; pattern specification process; positive regulation of Notch signaling pathway; positive regulation of protein binding; regulation of Notch signaling pathway
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Reference #:
Q9Y644
(UniProtKB)
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Alt. Names/Synonyms: Beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; radical fringe; radical fringe homolog; RFNG; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
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Gene Symbols: RFNG
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Molecular weight:
36,424 Da
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Basal Isoelectric point:
9.3
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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