RFNG Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. Belongs to the glycosyltransferase 31 family. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.1.222; Membrane protein, integral; Motility/polarity/chemotaxis; Transferase
Chromosomal Location of human Ortholog: 17q25.3
Cellular Component:  extracellular region; Golgi membrane
Molecular Function:  metal ion binding; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
Biological Process:  animal organ morphogenesis; cell differentiation; nervous system development; pattern specification process; positive regulation of Notch signaling pathway; positive regulation of protein binding; regulation of Notch signaling pathway
Reference #:  Q9Y644 (UniProtKB)
Alt. Names/Synonyms: Beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; radical fringe; radical fringe homolog; RFNG; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Gene Symbols: RFNG
Molecular weight: 36,424 Da
Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
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RFNG

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein