CYBB Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Detected in neutrophils (at protein level). Note: This description may include information from UniProtKB.
Protein type: EC 1.-.-.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: Xp21.1-p11.4
Cellular Component:  dendrite; endoplasmic reticulum membrane; Golgi apparatus; integral component of plasma membrane; NADPH oxidase complex; neuronal cell body; nuclear envelope; perinuclear endoplasmic reticulum; phagocytic vesicle membrane; plasma membrane; rough endoplasmic reticulum; specific granule membrane; tertiary granule membrane
Molecular Function:  flavin adenine dinucleotide binding; heme binding; metal ion binding; protein binding; protein heterodimerization activity; superoxide-generating NADPH oxidase activity; voltage-gated ion channel activity
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cellular response to cadmium ion; cellular response to ethanol; cellular response to L-glutamine; cellular response to oxidative stress; electron transport chain; hydrogen peroxide biosynthetic process; hypoxia-inducible factor-1alpha signaling pathway; inflammatory response; innate immune response; ion transmembrane transport; neutrophil degranulation; oxidation-reduction process; positive regulation of angiogenesis; positive regulation of tumor necrosis factor biosynthetic process; regulation of ion transmembrane transport; respiratory burst; response to aldosterone; response to angiotensin; superoxide anion generation; superoxide metabolic process; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, X-linked; Immunodeficiency 34
Reference #:  P04839 (UniProtKB)
Alt. Names/Synonyms: AMCBX2; CGD; CGD91-phox; CY24B; CYBB; Cytochrome b(558) subunit beta; cytochrome b-245 beta chain; cytochrome b-245 beta polypeptide; Cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; Cytochrome b558 subunit beta; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; IMD34; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2; p22 phagocyte B-cytochrome; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit
Gene Symbols: CYBB
Molecular weight: 65,336 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene