ST3GAL1 Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. Belongs to the glycosyltransferase 29 family. Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - O-glycan biosynthesis; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 8q24.22
Cellular Component:  Golgi cisterna membrane; Golgi membrane; integral component of membrane
Molecular Function:  beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
Biological Process:  cellular protein modification process; keratan sulfate biosynthetic process; N-acetylneuraminate metabolic process; O-glycan processing; protein N-linked glycosylation; protein phosphorylation; sialylation
Reference #:  Q11201 (UniProtKB)
Alt. Names/Synonyms: Alpha 2,3-ST 1; Beta-galactoside alpha-2,3-sialyltransferase 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; DKFZp666E036; DKFZp779K2051; FLJ36548; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Gal-NAc6S; MGC9183; SIA4A; Sialyltransferase 4A; sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase); sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase); sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase); SIAT4; SIAT4-A; SIAT4A; SIATFL; ST3 beta-galactoside alpha-2,3-sialyltransferase 1; ST3Gal I; ST3GAL1; ST3GalA; ST3GalA.1; ST3GalI; ST3GalIA; ST3GalIA,1; ST3O
Gene Symbols: ST3GAL1
Molecular weight: 39,075 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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