rabphilin 3A Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component:  cell projection; cholinergic synapse; cytoplasmic vesicle; dendritic spine; extrinsic component of membrane; extrinsic component of synaptic vesicle membrane; membrane; neuromuscular junction; neuron projection; plasma membrane; postsynaptic membrane; protein-containing complex; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; inositol 1,4,5 trisphosphate binding; lipid binding; metal ion binding; phosphate ion binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein-containing complex binding; selenium binding; small GTPase binding; zinc ion binding
Biological Process:  dendritic spine organization; exocytosis; intracellular protein transport; protein transport; regulation of calcium ion-dependent exocytosis; regulation of NMDA receptor activity; spontaneous neurotransmitter secretion; synaptic vesicle priming
Reference #:  P47708 (UniProtKB)
Alt. Names/Synonyms: 2900002P20Rik; AU022689; AW108370; Doc2 family; Exophilin-1; rabphilin 3A; Rabphilin-3A; RP3A; Rph3a
Gene Symbols: Rph3a
Molecular weight: 75,489 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
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rabphilin 3A

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein