KLK14 Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Belongs to the peptidase S1 family. Kallikrein subfamily. Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level). Expressed in stratum corneum by sweat ducts and sweat glands and detected in sweat (at protein level). Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 19q13.41
Cellular Component:  extracellular region; extracellular space; secretory granule
Molecular Function:  serine-type endopeptidase activity
Biological Process:  epidermis morphogenesis; fertilization; negative regulation of G protein-coupled receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; proteolysis; seminal clot liquefaction
Reference #:  Q9P0G3 (UniProtKB)
Alt. Names/Synonyms: hK14; kallikrein 14; kallikrein related peptidase 14; Kallikrein-14; Kallikrein-like protein 6; kallikrein-related peptidase 14; KLK-L6; KLK14; KLKL6
Gene Symbols: KLK14
Molecular weight: 29,122 Da
Basal Isoelectric point: 9.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene