IDUA Belongs to the glycosyl hydrolase 39 family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase
Chromosomal Location of human Ortholog: 4p16.3
Cellular Component:  lysosomal lumen
Molecular Function:  L-iduronidase activity; signaling receptor binding
Biological Process:  dermatan sulfate catabolic process; disaccharide metabolic process; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; heparin catabolic process
Disease: Hurler Syndrome; Hurler-scheie Syndrome; Scheie Syndrome
Reference #:  P35475 (UniProtKB)
Alt. Names/Synonyms: Alpha-L-iduronidase; IDA; IDUA; iduronidase alpha-L-; iduronidase, alpha-L-; MPS1; MPSI; mucopolysaccharidosis type I
Gene Symbols: IDUA
Molecular weight: 72,670 Da
Basal Isoelectric point: 9.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein