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IDUA
Belongs to the glycosyl hydrolase 39 family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.2.1.76; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase |
| Chromosomal Location of human Ortholog: 4p16.3 |
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Cellular Component:
coated vesicle; lysosomal lumen
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Molecular Function:
hydrolase activity, hydrolyzing O-glycosyl compounds; L-iduronidase activity; signaling receptor binding
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Biological Process:
chondroitin sulfate catabolic process; dermatan sulfate catabolic process; disaccharide metabolic process; glycosaminoglycan catabolic process; heparin catabolic process
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Disease: Hurler Syndrome; Hurler-scheie Syndrome; Scheie Syndrome
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Reference #:
P35475
(UniProtKB)
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Alt. Names/Synonyms: Alpha-L-iduronidase; IDA; IDUA; iduronidase alpha-L-; iduronidase, alpha-L-; MPS1; MPSI; mucopolysaccharidosis type I
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Gene Symbols: IDUA
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Molecular weight:
72,670 Da
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Basal Isoelectric point:
9.25
Predict pI for various phosphorylation states
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