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GDPD1
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. Belongs to the glycerophosphoryl diester phosphodiesterase family. Widely expressed with high expression level in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.-.-; Membrane protein, integral; Membrane protein, multi-pass; Phosphodiesterase |
| Chromosomal Location of human Ortholog: 17q22 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; perinuclear region of cytoplasm
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Molecular Function:
lysophospholipase activity; metal ion binding; phosphoric diester hydrolase activity
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Biological Process:
glycerophospholipid catabolic process; N-acylethanolamine metabolic process
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Reference #:
Q8N9F7
(UniProtKB)
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Alt. Names/Synonyms: FLJ27503; FLJ37451; GDE4; GDPD1; Glycerophosphodiester phosphodiesterase 4; glycerophosphodiester phosphodiesterase domain containing 1; Glycerophosphodiester phosphodiesterase domain-containing protein 1; Lysophospholipase D GDPD1; MGC35046
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Gene Symbols: GDPD1
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Molecular weight:
36,167 Da
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Basal Isoelectric point:
8.66
Predict pI for various phosphorylation states
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