GDPD1 Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. Belongs to the glycerophosphoryl diester phosphodiesterase family. Widely expressed with high expression level in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Membrane protein, integral; Membrane protein, multi-pass; Phosphodiesterase
Chromosomal Location of human Ortholog: 17q22
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; perinuclear region of cytoplasm
Molecular Function:  lysophospholipase activity; metal ion binding; phosphoric diester hydrolase activity
Biological Process:  glycerophospholipid catabolic process; N-acylethanolamine metabolic process
Reference #:  Q8N9F7 (UniProtKB)
Alt. Names/Synonyms: FLJ27503; FLJ37451; GDE4; GDPD1; Glycerophosphodiester phosphodiesterase 4; glycerophosphodiester phosphodiesterase domain containing 1; Glycerophosphodiester phosphodiesterase domain-containing protein 1; Lysophospholipase D GDPD1; MGC35046
Gene Symbols: GDPD1
Molecular weight: 36,167 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene