rabphilin 3A Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component:  cell junction; cytosol; extrinsic component of membrane; neuron projection; protein-containing complex; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; inositol 1,4,5 trisphosphate binding; phosphate ion binding; phosphatidylinositol phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein-containing complex binding; Rab GTPase binding; selenium binding; zinc ion binding
Biological Process:  intracellular protein transport; spontaneous neurotransmitter secretion
Reference #:  Q9Y2J0 (UniProtKB)
Alt. Names/Synonyms: Exophilin-1; KIAA0985; rabphilin 3A homolog (mouse); Rabphilin-3A; RP3A; RPH3A
Gene Symbols: RPH3A
Molecular weight: 76,872 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
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rabphilin 3A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein