CRYAB May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373). Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Cellular Component:  cytoplasm; nucleus; protein-containing complex
Molecular Function:  metal ion binding; protein homodimerization activity; structural constituent of eye lens
Biological Process:  negative regulation of transcription, DNA-templated
Reference #:  Q7M2W6 (UniProtKB)
Alt. Names/Synonyms: Alpha-crystallin B chain; CRYAB; crystallin, alpha B
Gene Symbols: CRYAB
Molecular weight: 20,129 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene