RHEB Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. Ubiquitous. Highest levels observed in skeletal and cardiac muscle. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rheb
Chromosomal Location of mouse Ortholog: 5|5 A3
Cellular Component:  cytoplasm; dendrite; endoplasmic reticulum; glutamatergic synapse; Golgi apparatus; membrane; neuronal cell body; plasma membrane; postsynaptic density; spliceosomal complex
Molecular Function:  GDP binding; GTP binding; GTPase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein kinase binding
Biological Process:  negative regulation of cold-induced thermogenesis; positive regulation of oligodendrocyte differentiation; positive regulation of TOR signaling; regulation of postsynapse organization; regulation of TOR signaling; regulation of type B pancreatic cell development; signal transduction; small GTPase mediated signal transduction
Reference #:  Q921J2 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein Rheb; OTTMUSP00000027651; Ras homolog enriched in brain; RAS-homolog enriched in brain; Rheb; Rheb1
Gene Symbols: Rheb
Molecular weight: 20,451 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  mTOR Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene