PIP5K1B Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid
Chromosomal Location of Human Ortholog: 19|19 B
Cellular Component:  cytosol; membrane; uropod
Molecular Function:  1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; kinase activity; nucleotide binding; phosphatidylinositol phosphate kinase activity; protein binding; transferase activity
Biological Process:  phosphatidylinositol biosynthetic process; phosphatidylinositol metabolic process; phosphorylation
Reference #:  P70181 (UniProtKB)
Alt. Names/Synonyms: AI844522; Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Phosphatidylinositol-4-phosphate 5-kinase type I alpha; Phosphatidylinositol-4-phosphate 5-kinase type I beta; Phosphatidylinositol-4-phosphate 5-kinase type-1 beta; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; PI4P5K-I[b]; PI51B; PIP5K1-beta; Pip5k1a; Pip5k1b; PIP5KIalpha; PIP5KIbeta; Pipk5a; Pipk5b; PtdIns(4)P-5-kinase 1 beta; STM7
Gene Symbols: Pip5k1b
Molecular weight: 60,803 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
Select Structure to View Below

PIP5K1B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene