C/EBP-epsilon Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation. Belongs to the bZIP family. C/EBP subfamily. Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  cellular response to lipopolysaccharide; cytokine biosynthetic process; defense response; defense response to bacterium; granulocyte differentiation; macrophage differentiation; phagocytosis; positive regulation of transcription by RNA polymerase II
Disease: Specific Granule Deficiency
Reference #:  Q15744 (UniProtKB)
Alt. Names/Synonyms: C/EBP epsilon; C/EBP-epsilon; CCAAT/enhancer binding protein (C/EBP), epsilon; CCAAT/enhancer-binding protein epsilon; CEBPE; CRP1
Gene Symbols: CEBPE
Molecular weight: 30,603 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
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C/EBP-epsilon

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB