BARD1 the BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Colocalizes with BRCA1 into discrete subnuclear foci during S phase. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. Defects in BARD1 gene are found in primary breast, ovarian and uterine cancers. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1|1 C3
Cellular Component:  BRCA1-A complex; BRCA1-BARD1 complex; cytoplasm; cytoplasmic ribonucleoprotein granule; nuclear speck; nucleus
Molecular Function:  metal ion binding; protein heterodimerization activity; protein homodimerization activity; RNA binding; transferase activity
Biological Process:  cellular response to DNA damage stimulus; DNA repair; negative regulation of apoptotic process; negative regulation of protein export from nucleus; positive regulation of apoptotic process; protein K6-linked ubiquitination; protein ubiquitination; regulation of phosphorylation
Reference #:  O70445 (UniProtKB)
Alt. Names/Synonyms: BARD-1; Bard1; BRCA1 associated RING domain 1; BRCA1-associated RING domain protein 1; ENSMUSG00000060893; ENSMUSG00000073653
Gene Symbols: Bard1
Molecular weight: 84,254 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene