BARD1 E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 2q35
Cellular Component:  BRCA1-A complex; BRCA1-BARD1 complex; cytoplasm; cytoplasmic ribonucleoprotein granule; nuclear speck; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function:  kinase binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA binding; ubiquitin-protein transferase activity
Biological Process:  cell cycle arrest; cellular response to DNA damage stimulus; DNA double-strand break processing; DNA replication; double-strand break repair via nonhomologous end joining; negative regulation of apoptotic process; negative regulation of mRNA 3'-end processing; negative regulation of protein export from nucleus; positive regulation of apoptotic process; positive regulation of protein catabolic process; protein deubiquitination; protein K6-linked ubiquitination; protein ubiquitination; regulation of phosphorylation; regulation of signal transduction by p53 class mediator; tissue homeostasis
Disease: Breast Cancer
Reference #:  Q99728 (UniProtKB)
Alt. Names/Synonyms: BARD-1; BARD1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
Gene Symbols: BARD1
Molecular weight: 86,648 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
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BARD1

Protein Structure Not Found.


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