BARD1 E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 2q35
Cellular Component:  BRCA1-A complex; BRCA1-B complex; BRCA1-BARD1 complex; BRCA1-C complex; cytoplasm; cytoplasmic ribonucleoprotein granule; nuclear speck; nuclear ubiquitin ligase complex; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function:  kinase binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA binding; ubiquitin-protein transferase activity
Biological Process:  cellular response to DNA damage stimulus; cellular response to ionizing radiation; DNA repair; DNA strand resection involved in replication fork processing; histone H2A K63-linked deubiquitination; histone H2A monoubiquitination; homologous recombination; mitotic G2/M transition checkpoint; negative regulation of apoptotic process; negative regulation of cell cycle; negative regulation of mRNA 3'-end processing; negative regulation of protein export from nucleus; positive regulation of apoptotic process; positive regulation of protein catabolic process; protein autoubiquitination; protein K6-linked ubiquitination; protein polyubiquitination; protein ubiquitination; regulation of cell cycle; regulation of DNA damage checkpoint; regulation of DNA repair; regulation of phosphorylation; tissue homeostasis
Disease: Breast Cancer
Reference #:  Q99728 (UniProtKB)
Alt. Names/Synonyms: BARD-1; BARD1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
Gene Symbols: BARD1
Molecular weight: 86,648 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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