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Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Belongs to the SNW family. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Spliceosome; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 14q24.3 |
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Cellular Component:
catalytic step 2 spliceosome; nuclear body; nuclear matrix; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2-type catalytic step 2 spliceosome
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Molecular Function:
enzyme binding; Notch binding; nuclear androgen receptor binding; nuclear receptor binding; nuclear retinoic acid receptor binding; nuclear vitamin D receptor binding; protein binding; SMAD binding; transcription coactivator activity; transcription corepressor activity
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Biological Process:
cellular response to retinoic acid; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; mRNA splicing, via spliceosome; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation by host of viral transcription; positive regulation of mRNA splicing, via spliceosome; positive regulation of neurogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of vitamin D receptor signaling pathway; regulation of retinoic acid receptor signaling pathway; regulation of transcription by RNA polymerase II; regulation of vitamin D receptor signaling pathway; retinoic acid receptor signaling pathway
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Reference #:
Q13573
(UniProtKB)
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Alt. Names/Synonyms: Bx42; FUN20; homolog of Drosophila BX42; MGC119379; NCOA-62; Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; Prp45; PRPF45; SKI interacting protein; Ski-interacting protein; SKIIP; SKIP; SKIP1; SNW domain containing 1; SNW domain-containing protein 1; SNW1
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Gene Symbols: SNW1
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Molecular weight:
61,494 Da
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Basal Isoelectric point:
9.52
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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