BVR
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. Liver. Note: This description may include information from UniProtKB.
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Protein type: ATYPICAL group; BLVRA family; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) |
Chromosomal Location of human Ortholog: 7p13 |
Cellular Component:
cytosol
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Molecular Function:
biliberdin reductase NAD+ activity; biliverdin reductase (NAD(P)+) activity; biliverdin reductase (NADP+) activity; nucleotide binding; protein binding; zinc ion binding
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Biological Process:
heme catabolic process
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Disease: Hyperbiliverdinemia
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Reference #:
P53004
(UniProtKB)
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Alt. Names/Synonyms: BIEA; Biliverdin reductase A; Biliverdin-IX alpha-reductase; BLVR; BLVRA; BVR; BVR A; BVRA; testis tissue sperm-binding protein Li 61n
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Gene Symbols: BLVRA
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Molecular weight:
33,428 Da
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Basal Isoelectric point:
6.06
Predict pI for various phosphorylation states
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