BVR Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. Liver. Note: This description may include information from UniProtKB.
Protein type: ATYPICAL group; BLVRA family; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 7p13
Cellular Component:  cytosol
Molecular Function:  biliberdin reductase NAD+ activity; biliverdin reductase (NAD(P)+) activity; biliverdin reductase (NADP+) activity; nucleotide binding; protein binding; zinc ion binding
Biological Process:  heme catabolic process
Disease: Hyperbiliverdinemia
Reference #:  P53004 (UniProtKB)
Alt. Names/Synonyms: BIEA; Biliverdin reductase A; Biliverdin-IX alpha-reductase; BLVR; BLVRA; BVR; BVR A; BVRA; testis tissue sperm-binding protein Li 61n
Gene Symbols: BLVRA
Molecular weight: 33,428 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB