PLCG1 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase
Cellular Component:  COP9 signalosome; lamellipodium; ruffle
Molecular Function:  calcium ion binding; protein binding
Biological Process:  cellular response to epidermal growth factor stimulus; cellular response to vascular endothelial growth factor stimulus; in utero embryonic development; phospholipid catabolic process; positive regulation of epithelial cell migration
Reference #:  P08487 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; BOS_13285; Phosphoinositide phospholipase C; phospholipase C, gamma 1; Phospholipase C-gamma-1; PLC-148; PLC-gamma-1; PLC-II; PLCG1
Gene Symbols: PLCG1
Molecular weight: 148,313 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  T Cell Receptor Signaling
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PLCG1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene