osteopontin Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. Belongs to the osteopontin family. Bone. Found in plasma. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component:  cell projection; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi apparatus; perinuclear region of cytoplasm
Molecular Function:  cytokine activity; integrin binding; protein binding
Biological Process:  androgen catabolic process; biomineral tissue development; cell adhesion; cellular protein metabolic process; cellular response to testosterone stimulus; decidualization; embryo implantation; extracellular matrix organization; inflammatory response; negative regulation of collateral sprouting of intact axon in response to injury; positive regulation of estradiol secretion; positive regulation of transcription, DNA-templated; post-translational protein modification; regulation of signaling receptor activity; response to steroid hormone; response to vitamin D
Reference #:  P10451 (UniProtKB)
Alt. Names/Synonyms: BNSP; Bone sialoprotein 1; bone sialoprotein I; BSPI; early T-lymphocyte activation 1; ETA-1; MGC110940; Nephropontin; OPN; Osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; OSTP; Secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); secreted phosphoprotein-1 (osteopontin, bone sialoprotein); SPP-1; SPP1; SPP1/CALPHA1 fusion; Urinary stone protein; Uropontin
Gene Symbols: SPP1
Molecular weight: 35,423 Da
Basal Isoelectric point: 4.37  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein