ROCK2 Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); ROCK subfamily
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component:  centrosome; cytoplasmic ribonucleoprotein granule; cytosol; nucleus; plasma membrane
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity; Rho GTPase binding; Rho-dependent protein serine/threonine kinase activity; structural molecule activity; tau protein binding; tau-protein kinase activity
Biological Process:  aortic valve morphogenesis; cellular response to acetylcholine; cellular response to testosterone stimulus; centrosome duplication; cortical actin cytoskeleton organization; ephrin receptor signaling pathway; G protein-coupled receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; mRNA destabilization; negative regulation of angiogenesis; negative regulation of bicellular tight junction assembly; negative regulation of biomineral tissue development; negative regulation of gene expression; negative regulation of myosin-light-chain-phosphatase activity; negative regulation of nitric oxide biosynthetic process; negative regulation of protein localization to lysosome; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of amyloid precursor protein catabolic process; positive regulation of amyloid-beta formation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of cardiac muscle hypertrophy; positive regulation of cell migration; positive regulation of centrosome duplication; positive regulation of connective tissue growth factor production; positive regulation of connective tissue replacement; positive regulation of endothelial cell migration; positive regulation of fibroblast growth factor production; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of protein localization to early endosome; positive regulation of protein phosphorylation; positive regulation of stress fiber assembly; protein localization to plasma membrane; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of angiotensin-activated signaling pathway; regulation of blood vessel diameter; regulation of cell adhesion; regulation of cell motility; regulation of cellular response to hypoxia; regulation of circadian rhythm; regulation of establishment of cell polarity; regulation of establishment of endothelial barrier; regulation of focal adhesion assembly; regulation of keratinocyte differentiation; regulation of neurological system process; regulation of protein metabolic process; regulation of stress fiber assembly; response to angiotensin; response to ischemia; response to transforming growth factor beta; Rho protein signal transduction; rhythmic process; smooth muscle contraction; vascular endothelial growth factor receptor signaling pathway; viral RNA genome replication
Reference #:  O75116 (UniProtKB)
Alt. Names/Synonyms: KIAA0619; p164 ROCK-2; Rho kinase 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; ROCK2
Gene Symbols: ROCK2
Molecular weight: 160,900 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Apoptosis Regulation  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ROCK2

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