MBLR Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 19|19 C3
Cellular Component:  nucleus; PcG protein complex; PRC1 complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein domain specific binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  histone H2A-K119 monoubiquitination; inactivation of X chromosome by genetic imprinting; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  Q99NA9 (UniProtKB)
Alt. Names/Synonyms: 4933407A11Rik; AI604840; Mblr; Mel18 and Bmi1-like RING finger; Mel18 and Bmi1-like RING finger protein; Mel18- and Bmi1-like RING finger protein; MGC106622; Pcgf6; polycomb group ring finger 6; Polycomb group RING finger protein 6; RING finger protein 134; Rnf1; Rnf134
Gene Symbols: Pcgf6
Molecular weight: 39,820 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
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MBLR

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene