H3 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13|13 A3.1
Cellular Component:  nuclear chromosome; nuclear nucleosome; nucleosome; nucleus; protein-containing complex
Biological Process:  DNA replication-dependent nucleosome assembly; nucleosome assembly; protein heterotetramerization; regulation of gene silencing
Reference #:  P68433 (UniProtKB)
Alt. Names/Synonyms: H3.1-221; H3.1-291; H3.1-I; H31; H3a; H3g; H3h; H3i; Hist1h3a; Hist1h3g; Hist1h3h; Hist1h3i; histone 1, H3a; histone cluster 1, H3a; Histone H3.1; OTTMUSP00000000548
Gene Symbols: Hist1h3a
Molecular weight: 15,273 Da
Basal Isoelectric point: 11.13  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Histone Methylation  |  NF-kB Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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H3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene