LSD1 Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. Belongs to the flavin monoamine oxidase family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor
Chromosomal Location of Human Ortholog: 4 D3|4 68.8 cM
Cellular Component:  DNA repair complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; protein-containing complex; transcription factor complex
Molecular Function:  androgen receptor binding; chromatin binding; demethylase activity; DNA binding; DNA-binding transcription factor activity; enzyme binding; flavin adenine dinucleotide binding; histone demethylase activity; histone demethylase activity (H3-dimethyl-K4 specific); histone demethylase activity (H3-K4 specific); histone demethylase activity (H3-K9 specific); MRF binding; nuclear receptor transcription coactivator activity; oxidoreductase activity; p53 binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; telomeric DNA binding; telomeric repeat-containing RNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  cell proliferation; cellular response to gamma radiation; cellular response to UV; chromatin organization; chromatin silencing; granulocyte differentiation; guanine metabolic process; histone H3-K4 demethylation; histone H3-K9 demethylation; in utero embryonic development; multicellular organism development; muscle cell development; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA-binding transcription factor activity; negative regulation of histone H3-K4 methylation; negative regulation of histone H3-K9 methylation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of neurogenesis; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron projection extension; oxidation-reduction process; pituitary gland development; positive regulation of cell size; positive regulation of chromatin binding; positive regulation of cold-induced thermogenesis; positive regulation of DNA-binding transcription factor activity; positive regulation of erythrocyte differentiation; positive regulation of histone ubiquitination; positive regulation of hormone biosynthetic process; positive regulation of megakaryocyte differentiation; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron projection development; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; protein demethylation; regulation of cellular protein localization; regulation of double-strand break repair via homologous recombination; regulation of neurogenesis; regulation of primitive erythrocyte differentiation; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q6ZQ88 (UniProtKB)
Alt. Names/Synonyms: 1810043O07Rik; AA408884; amine oxidase (flavin containing) domain 2; Aof2; BRAF35-HDAC complex protein BHC110; D4Ertd478e; Flavin-containing amine oxidase domain-containing protein 2; Kdm1; Kdm1a; Kiaa0601; Lsd1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; mKIAA0601
Gene Symbols: Kdm1a
Molecular weight: 92,851 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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LSD1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA