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EEF1D
Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). Belongs to the EF-1-beta/EF-1-delta family. Isoform 2 is specifically expressed in brain, cerebellum and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation elongation |
| Chromosomal Location of mouse Ortholog: 15|15 D3 |
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Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum; eukaryotic translation elongation factor 1 complex; fibrillar center; glutamatergic synapse; nucleoplasm; nucleus; synapse
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Molecular Function:
DNA binding; DNA-binding transcription factor binding; guanyl-nucleotide exchange factor activity; heat shock protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; translation elongation factor activity
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Biological Process:
cellular response to heat; cellular response to ionizing radiation; positive regulation of transcription by RNA polymerase II; translation; translational elongation
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Reference #:
P57776
(UniProtKB)
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Alt. Names/Synonyms: 1700026P12Rik; 5730529A16Rik; AL023999; Eef1d; EF-1-delta; EF1D; Elongation factor 1-delta; eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); OTTMUSP00000021366; OTTMUSP00000021367
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Gene Symbols: Eef1d
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Molecular weight:
31,293 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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CST Pathways:
Translational Control
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