EEF1D Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). Belongs to the EF-1-beta/EF-1-delta family. Isoform 2 is specifically expressed in brain, cerebellum and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation elongation
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component:  cytoplasm; cytosol; eukaryotic translation elongation factor 1 complex; fibrillar center; nucleus
Molecular Function:  DNA binding; protein binding; translation elongation factor activity; translation factor activity, RNA binding
Biological Process:  cellular response to ionizing radiation; translational elongation
Reference #:  P29692 (UniProtKB)
Alt. Names/Synonyms: Antigen NY-CO-4; EEF1D; EF-1-delta; EF-1D; EF1D; Elongation factor 1-delta; eukaryotic translation elongation factor 1 delta; eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); FLJ20897; FP1047; guanine nucleotide exchange protein
Gene Symbols: EEF1D
Molecular weight: 31,122 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
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EEF1D

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene