HBP1 Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12|12 A3
Cellular Component:  nuclear speck; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  negative regulation of lipid transport; negative regulation of macrophage derived foam cell differentiation; negative regulation of reactive oxygen species biosynthetic process; negative regulation of transcription by RNA polymerase II; positive regulation of potassium ion transport; regulation of transcription, DNA-templated; Wnt signaling pathway
Reference #:  Q8R316 (UniProtKB)
Alt. Names/Synonyms: 1700058O05Rik; BE629963; C330012F01Rik; C86454; Hbp1; High mobility group box transcription factor 1; HMG box transcription factor 1; HMG box-containing protein 1
Gene Symbols: Hbp1
Molecular weight: 57,645 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene