GRK1 Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Retinal-specific. Expressed in rods and cones cells. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 13q34
Cellular Component:  cytoplasm; photoreceptor disc membrane
Molecular Function:  ATP binding; protein kinase activity; rhodopsin kinase activity
Biological Process:  protein autophosphorylation; protein phosphorylation; regulation of G protein-coupled receptor signaling pathway; regulation of rhodopsin mediated signaling pathway; regulation of signal transduction; rhodopsin mediated signaling pathway; visual perception
Disease: Oguchi Disease 2
Reference #:  Q15835 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor kinase 1; GPRK1; GRK1; Rhodopsin kinase; Rhodopsin kinase GRK1; RHOK; RK
Gene Symbols: GRK1
Molecular weight: 63,526 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein