GSTA4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). Belongs to the GST superfamily. Alpha family. Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 9|9 E1
Cellular Component:  cytoplasm; mitochondrion
Molecular Function:  drug binding; glutathione binding; glutathione transferase activity; transferase activity
Biological Process:  glutathione metabolic process; xenobiotic metabolic process
Reference #:  P24472 (UniProtKB)
Alt. Names/Synonyms: Glutathione S-transferase 5.7; Glutathione S-transferase A4; glutathione S-transferase, alpha 4; GST 5.7; GST A4-4; GST class-alpha member 4; GST5.7; Gsta; Gsta4; GSTA4-4; mGsta4
Gene Symbols: Gsta4
Molecular weight: 25,564 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene