GSTA4 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). Belongs to the GST superfamily. Alpha family. Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 6p12.2
Cellular Component:  cytosol
Molecular Function:  glutathione transferase activity; identical protein binding; protein binding; protein homodimerization activity
Biological Process:  glutathione derivative biosynthetic process; glutathione metabolic process; xenobiotic metabolic process
Reference #:  O15217 (UniProtKB)
Alt. Names/Synonyms: DKFZp686D21185; glutathione S-alkyltransferase A4; glutathione S-aralkyltransferase A4; glutathione S-aryltransferase A4; Glutathione S-transferase A4; Glutathione S-transferase A4-4; glutathione S-transferase alpha 4; glutathione transferase A4-4; GST class-alpha member 4; GSTA4; GSTA4-4; GTA4; S-(hydroxyalkyl)glutathione lyase A4
Gene Symbols: GSTA4
Molecular weight: 25,704 Da
Basal Isoelectric point: 7.89  Predict pI for various phosphorylation states
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GSTA4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene