RIMS2 Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes. Expressed in melanocytes (PubMed:23999003). 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of rat Ortholog: 7q31
Cellular Component:  cell projection; cytoskeleton of presynaptic active zone; GABA-ergic synapse; glutamatergic synapse; inhibitory synapse; membrane; photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; synapse
Molecular Function:  metal ion binding; protein binding; protein domain specific binding; protein-containing complex binding; protein-macromolecule adaptor activity; small GTPase binding; structural constituent of presynaptic active zone; transmembrane transporter binding
Biological Process:  adenylate cyclase-modulating G protein-coupled receptor signaling pathway; calcium ion-regulated exocytosis of neurotransmitter; calcium-ion regulated exocytosis; cell differentiation; establishment of localization in cell; exocytosis; insulin secretion; intracellular protein transport; maintenance of presynaptic active zone structure; neurotransmitter secretion; neurotransmitter transport; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; positive regulation of synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; regulation of exocytosis; regulation of membrane potential; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis; spontaneous neurotransmitter secretion; synaptic vesicle docking; synaptic vesicle priming
Reference #:  Q9JIS1 (UniProtKB)
Alt. Names/Synonyms: Nim2; Rab-3-interacting molecule 2; rab3-interacting molecule 2; regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; Rims2
Gene Symbols: Rims2
Molecular weight: 175,913 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
Select Structure to View Below

RIMS2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene