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RIMS2
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes. Expressed in melanocytes (PubMed:23999003). 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of rat Ortholog: 7q31 |
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Cellular Component:
cell projection; cytoskeleton of presynaptic active zone; GABA-ergic synapse; glutamatergic synapse; inhibitory synapse; membrane; photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; synapse
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Molecular Function:
metal ion binding; protein binding; protein domain specific binding; protein-containing complex binding; protein-macromolecule adaptor activity; small GTPase binding; structural constituent of presynaptic active zone; transmembrane transporter binding
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Biological Process:
adenylate cyclase-modulating G protein-coupled receptor signaling pathway; calcium ion-regulated exocytosis of neurotransmitter; calcium-ion regulated exocytosis; cell differentiation; establishment of localization in cell; exocytosis; insulin secretion; intracellular protein transport; maintenance of presynaptic active zone structure; neurotransmitter secretion; neurotransmitter transport; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; positive regulation of synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; regulation of exocytosis; regulation of membrane potential; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis; spontaneous neurotransmitter secretion; synaptic vesicle docking; synaptic vesicle priming
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Reference #:
Q9JIS1
(UniProtKB)
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Alt. Names/Synonyms: Nim2; Rab-3-interacting molecule 2; rab3-interacting molecule 2; regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; Rims2
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Gene Symbols: Rims2
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Molecular weight:
175,913 Da
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Basal Isoelectric point:
9.45
Predict pI for various phosphorylation states
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