RIMS2 Rab effector involved in exocytosis. May act as scaffold protein. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q31
Cellular Component:  cell junction; cytoskeleton of presynaptic active zone; GABA-ergic synapse; glutamatergic synapse; inhibitory synapse; membrane; photoreceptor ribbon synapse; presynaptic active zone; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; synapse
Molecular Function:  ion channel binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; Rab GTPase binding; structural constituent of presynaptic active zone
Biological Process:  calcium ion regulated exocytosis; calcium ion-regulated exocytosis of neurotransmitter; cAMP-mediated signaling; cell differentiation; exocytosis; insulin secretion; intracellular protein transport; neurotransmitter secretion; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; positive regulation of synaptic transmission; regulation of exocytosis; regulation of membrane potential; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis; spontaneous neurotransmitter secretion; synaptic vesicle docking; synaptic vesicle priming
Reference #:  Q9JIS1 (UniProtKB)
Alt. Names/Synonyms: Nim2; Rab-3-interacting molecule 2; rab3-interacting molecule 2; regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; Rims2
Gene Symbols: Rims2
Molecular weight: 175,913 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
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RIMS2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene