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RIMS2
Rab effector involved in exocytosis. May act as scaffold protein. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 7q31 |
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Cellular Component:
cell junction; cytoskeleton of presynaptic active zone; GABA-ergic synapse; glutamatergic synapse; inhibitory synapse; membrane; photoreceptor ribbon synapse; presynaptic active zone; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; synapse
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Molecular Function:
ion channel binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; Rab GTPase binding; structural constituent of presynaptic active zone
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Biological Process:
calcium ion regulated exocytosis; calcium ion-regulated exocytosis of neurotransmitter; cAMP-mediated signaling; cell differentiation; exocytosis; insulin secretion; intracellular protein transport; neurotransmitter secretion; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; positive regulation of synaptic transmission; regulation of exocytosis; regulation of membrane potential; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis; spontaneous neurotransmitter secretion; synaptic vesicle docking; synaptic vesicle priming
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Reference #:
Q9JIS1
(UniProtKB)
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Alt. Names/Synonyms: Nim2; Rab-3-interacting molecule 2; rab3-interacting molecule 2; regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; Rims2
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Gene Symbols: Rims2
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Molecular weight:
175,913 Da
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Basal Isoelectric point:
9.45
Predict pI for various phosphorylation states
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