RIMS2 Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes. Expressed in melanocytes (PubMed:23999003). 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8q22.3
Cellular Component:  cell junction; presynaptic active zone
Molecular Function:  ion channel binding; metal ion binding; protein binding
Biological Process:  calcium ion regulated exocytosis; calcium ion-regulated exocytosis of neurotransmitter; cAMP-mediated signaling; insulin secretion; intracellular protein transport; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; regulation of exocytosis; regulation of membrane potential; spontaneous neurotransmitter secretion
Disease: Cone-rod Synaptic Disorder Syndrome, Congenital Nonprogressive
Reference #:  Q9UQ26 (UniProtKB)
Alt. Names/Synonyms: CRSDS; DKFZp781A0653; KIAA0751; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; OBOE; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; RAB3 interacting protein 3; rab3-interacting molecule 2; Rab3-interacting protein; RAB3IP3; regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; RIM2; RIMS2
Gene Symbols: RIMS2
Molecular weight: 160,403 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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