RIMS2 Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes. Expressed in melanocytes (PubMed:23999003). 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 15 B3.1|15 15.45 cM
Cellular Component:  cell junction; cytoskeleton of presynaptic active zone; GABA-ergic synapse; glutamatergic synapse; inhibitory synapse; membrane; neuron projection; photoreceptor ribbon synapse; presynaptic active zone; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; synapse
Molecular Function:  ion channel binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; Rab GTPase binding; structural constituent of presynaptic active zone
Biological Process:  calcium ion regulated exocytosis; calcium ion-regulated exocytosis of neurotransmitter; cAMP-mediated signaling; cell differentiation; exocytosis; insulin secretion; intracellular protein transport; neurotransmitter secretion; neurotransmitter transport; positive regulation of dendrite extension; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of inhibitory postsynaptic potential; positive regulation of synaptic transmission; regulation of exocytosis; regulation of membrane potential; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis; spontaneous neurotransmitter secretion; synaptic vesicle docking; synaptic vesicle priming
Reference #:  Q9EQZ7 (UniProtKB)
Alt. Names/Synonyms: 2810036I15Rik; AW048769; mKIAA0751; Rab-3-interacting molecule 2; Rab-3-interacting protein 2; Rab3 interacting protein 1; Rab3 interacting protein 2; rab3-interacting molecule 2; rab3-interacting protein 2; Rab3ip2; regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; Rim2(+40A); Rim2(+44A); Rim2(+4A); Rims2; Serg2; synaptic exocytosis regulator 2; synaptotagmin 3, related sequence; Syt3-rs
Gene Symbols: Rims2
Molecular weight: 172,863 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene